Structural basis of tyrosine sulfation and V(H)-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of...

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Bibliographic Details
Main Authors: Huang, Chih-chin, Venturi, Miro, Majeed, Shahzad, Moore, Michael J., Phogat, Sanjay, Zhang, Mei-Yun, Dimitrov, Dimiter S., Hendrickson, Wayne A., Robinson, James, Sodroski, Joseph, Wyatt, Richard, Choe, Hyeryun, Farzan, Michael, Kwong, Peter D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC365685/
https://ncbi.nlm.nih.gov/pubmed/14981267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308527100
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