Structural basis of tyrosine sulfation and V(H)-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of...

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Detalhes bibliográficos
Main Authors: Huang, Chih-chin, Venturi, Miro, Majeed, Shahzad, Moore, Michael J., Phogat, Sanjay, Zhang, Mei-Yun, Dimitrov, Dimiter S., Hendrickson, Wayne A., Robinson, James, Sodroski, Joseph, Wyatt, Richard, Choe, Hyeryun, Farzan, Michael, Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC365685/
https://ncbi.nlm.nih.gov/pubmed/14981267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308527100
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