CD4 Binding Site Antibodies Inhibit Human Immunodeficiency Virus gp120 Envelope Glycoprotein Interaction with CCR5

The human immunodeficiency virus type 1 (HIV-1) gp120 exterior glycoprotein is conformationally flexible. Upon binding the host cell receptor, CD4, gp120 assumes a conformation that is able to bind the chemokine receptors CCR5 or CXCR4, which act as coreceptors for the virus. CD4-binding-site (CD4BS...

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Bibliographic Details
Main Authors: Raja, Aarti, Venturi, Miro, Kwong, Peter, Sodroski, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC140634/
https://ncbi.nlm.nih.gov/pubmed/12477875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.713-718.2003
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