Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein

The human immunodeficiency virus type 1 (HIV-1) gp120 exterior envelope glycoprotein is conformationally flexible. Upon binding to the host cell receptor CD4, gp120 assumes a conformation that is recognized by the second receptor, CCR5 and/or CXCR4, and by the CD4-induced (CD4i) antibodies. Guided b...

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Main Authors: Xiang, Shi-Hua, Kwong, Peter D., Gupta, Rishi, Rizzuto, Carlo D., Casper, David J., Wyatt, Richard, Wang, Liping, Hendrickson, Wayne A., Doyle, Michael L., Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Structure and Assembly
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136507/
https://ncbi.nlm.nih.gov/pubmed/12208966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.19.9888-9899.2002
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