Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein

The human immunodeficiency virus type 1 (HIV-1) gp120 exterior envelope glycoprotein is conformationally flexible. Upon binding to the host cell receptor CD4, gp120 assumes a conformation that is recognized by the second receptor, CCR5 and/or CXCR4, and by the CD4-induced (CD4i) antibodies. Guided b...

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izdano v:	J Virol
Principais autores:	Xiang, Shi-Hua, Kwong, Peter D., Gupta, Rishi, Rizzuto, Carlo D., Casper, David J., Wyatt, Richard, Wang, Liping, Hendrickson, Wayne A., Doyle, Michael L., Sodroski, Joseph
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2002
Teme:	Structure and Assembly
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12208966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.19.9888-9899.2002
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