CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization

Human immunodeficiency virus type 1 (HIV-1) entry into target cells involves sequential binding of the gp120 exterior envelope glycoprotein to CD4 and to specific chemokine receptors. Soluble CD4 (sCD4) is thought to mimic membrane-anchored CD4, and its binding alters the conformation of the HIV-1 e...

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Hlavní autoři: Sullivan, Nancy, Sun, Ying, Sattentau, Quentin, Thali, Markus, Wu, Dona, Denisova, Galina, Gershoni, Jonathan, Robinson, James, Moore, John, Sodroski, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1998
Témata:
Animal Viruses
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC109994/
https://ncbi.nlm.nih.gov/pubmed/9573233
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