Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain

Biochemical and structural studies of fragments of the ectodomain of the human immunodeficiency virus type 1 (HIV-1) gp41 transmembrane envelope glycoprotein have demonstrated that the molecular contacts between alpha helices allow the formation of a trimeric coiled coil. By introducing cysteine res...

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Detalhes bibliográficos
Main Authors: Farzan, Michael, Choe, Hyeryun, Desjardins, Elizabeth, Sun, Ying, Kuhn, Jens, Cao, Jie, Archambault, Danielle, Kolchinsky, Peter, Koch, Markus, Wyatt, Richard, Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Animal Viruses
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110020/
https://ncbi.nlm.nih.gov/pubmed/9696864
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