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Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy

NMR spectroscopic characterization of the structure or the dynamics of proteins generally requires the production of samples isotopically enriched in (15)N, (13)C, or (2)H. The bacterial expression systems currently in use to obtain isotopic enrichment, however, cannot produce a number of eukaryotic...

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Bibliografiske detaljer
Main Authors: Sastry, Mallika, Xu, Ling, Georgiev, Ivelin S., Bewley, Carole A., Nabel, Gary J., Kwong, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133704/
https://ncbi.nlm.nih.gov/pubmed/21667299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-011-9506-4
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