Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with the HIV-1 surface protein

Ligand affinities can be optimized by interfacial cavity filling. A hollow (Phe43 cavity) between HIV-1 surface protein (gp120) and cluster of differentiation 4 (CD4) receptor, extends beyond residue phenylalanine 43 of CD4 and cannot be fully accessed by natural amino acids. To increase HIV-1 gp120...

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Main Authors: Morellato-Castillo, Laurence, Acharya, Priyamvada, Combes, Olivier, Michiels, Johan, Descours, Anne, Ramos, Oscar H. P., Yang, Yongping, Vanham, Guido, Ariën, Kevin K., Kwong, Peter D., Martin, Loïc, Kessler, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812931/
https://ncbi.nlm.nih.gov/pubmed/23710622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4002988
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