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Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with the HIV-1 surface protein
Ligand affinities can be optimized by interfacial cavity filling. A hollow (Phe43 cavity) between HIV-1 surface protein (gp120) and cluster of differentiation 4 (CD4) receptor, extends beyond residue phenylalanine 43 of CD4 and cannot be fully accessed by natural amino acids. To increase HIV-1 gp120...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812931/ https://ncbi.nlm.nih.gov/pubmed/23710622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4002988 |
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