MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

BACKGROUND: Binding of the viral envelope protein (Env), and particularly of its gp120 subunit, to the cellular CD4 receptor is the first essential step of the HIV-1 entry process. The CD4 binding site (CD4bs) of gp120, and especially a recessed cavity occupied by the CD4 Phe43 residue, are known to...

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Main Authors: Grupping, Katrijn, Selhorst, Philippe, Michiels, Johan, Vereecken, Katleen, Heyndrickx, Leo, Kessler, Pascal, Vanham, Guido, Martin, Loïc, Ariën, Kevin K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408336/
https://ncbi.nlm.nih.gov/pubmed/22551420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-36
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