MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV(162P3) in Cynomolgus Macaques

In complement to an effective vaccine, development of potent anti-HIV microbicides remains an important priority. We have previously shown that the miniCD4 M48U1, a functional mimetic of sCD4 presented on a 27 amino-acid stable scaffold, inhibits a broad range of HIV-1 isolates at sub-nanomolar conc...

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Main Authors: Dereuddre-Bosquet, Nathalie, Morellato-Castillo, Laurence, Brouwers, Joachim, Augustijns, Patrick, Bouchemal, Kawthar, Ponchel, Gilles, Ramos, Oscar H. P., Herrera, Carolina, Stefanidou, Martha, Shattock, Robin, Heyndrickx, Leo, Vanham, Guido, Kessler, Pascal, Le Grand, Roger, Martin, Loïc
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516572/
https://ncbi.nlm.nih.gov/pubmed/23236282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003071
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