Supersaturation-limited Amyloid Fibrillation of Insulin Revealed by Ultrasonication

Amyloid fibrils form in supersaturated solutions via a nucleation and growth mechanism. We proposed that ultrasonication may be an effective agitation to trigger nucleation that would otherwise not occur under the persistent metastability of supersaturation. However, the roles of supersaturation and...

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Bibliographic Details
Main Authors: Muta, Hiroya, Lee, Young-Ho, Kardos, József, Lin, Yuxi, Yagi, Hisashi, Goto, Yuji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140283/
https://ncbi.nlm.nih.gov/pubmed/24847058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566950
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