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Supersaturation-limited Amyloid Fibrillation of Insulin Revealed by Ultrasonication

Amyloid fibrils form in supersaturated solutions via a nucleation and growth mechanism. We proposed that ultrasonication may be an effective agitation to trigger nucleation that would otherwise not occur under the persistent metastability of supersaturation. However, the roles of supersaturation and...

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Bibliografiske detaljer
Main Authors: Muta, Hiroya, Lee, Young-Ho, Kardos, József, Lin, Yuxi, Yagi, Hisashi, Goto, Yuji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140283/
https://ncbi.nlm.nih.gov/pubmed/24847058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566950
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