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Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry

Amyloid fibrils form in supersaturated solutions via a nucleation and growth mechanism. Although the structural features of amyloid fibrils have become increasingly clearer, knowledge on the thermodynamics of fibrillation is limited. Furthermore, protein aggregation is not a target of calorimetry, o...

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Detalhes bibliográficos
Main Authors: Ikenoue, Tatsuya, Lee, Young-Ho, Kardos, József, Yagi, Hisashi, Ikegami, Takahisa, Naiki, Hironobu, Goto, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020073/
https://ncbi.nlm.nih.gov/pubmed/24753579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322602111
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