Copper is required for oncogenic BRAF signaling and tumorigenesis

The BRAF kinase is mutated, typically V600E, to induce an active oncogenic state in a large fraction of melanoma, thyroid, hairy cell leukemia, and to a lesser extent, a wide spectrum of other cancers(1,2). BRAF(V600E) phosphorylates and activates the kinases MEK1 and MEK2, which in turn phosphoryla...

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Bibliografiske detaljer
Main Authors: Brady, Donita C., Crowe, Matthew S., Turski, Michelle L., Hobbs, G. Aaron, Yao, Xiaojie, Chaikuad, Apirat, Knapp, Stefan, Xiao, Kunhong, Campbell, Sharon L., Thiele, Dennis J., Counter, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138975/
https://ncbi.nlm.nih.gov/pubmed/24717435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13180
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