Successful challenges using native E. coli asparaginase after hypersensitivity reactions to PEGylated E. coli asparaginase

PURPOSE: Asparaginase is an essential component of pediatric acute lymphoblastic leukemia (ALL) therapy. However, asparaginase-induced hypersensitivity reactions can compromise its efficacy either by directly influencing the pharmacokinetics of asparaginase or by leading to a discontinuation of aspa...

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Hauptverfasser: Fernandez, C.A., Stewart, E., Panetta, J.C., Wilkinson, M.R., Morrison, A.R., Finkelman, F.D., Sandlund, J.T., Pui, C.H, Jeha, S., Relling, M.V., Campbell, P.K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137479/
https://ncbi.nlm.nih.gov/pubmed/24771103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2464-2
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