Comparison of native E. coli and PEG asparaginase pharmacokinetics and pharmacodynamics in pediatric acute lymphoblastic leukemia

Asparaginase is used routinely in frontline clinical trials for the treatment of childhood acute lymphoblastic leukemia (ALL). The goals of this study were to assess the pharmacokinetics and pharmacodynamics of asparaginase and to mathematically model the dynamics between asparaginase and asparagine...

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Main Authors: Panetta, J.C., Gajjar, A., Hijiya, N., Hak, L.J., Cheng, C., Liu, W., Pui, C.H., Relling, M.V.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831746/
https://ncbi.nlm.nih.gov/pubmed/19741605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.162
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