Particle Conformation Regulates Antibody Access to a Conserved GII.4 Norovirus Blockade Epitope

GII.4 noroviruses (NoVs) are the primary cause of epidemic viral acute gastroenteritis. One primary obstacle to successful NoV vaccination is the extensive degree of antigenic diversity among strains. The major capsid protein of GII.4 strains is evolving rapidly, resulting in the emergence of new st...

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Autors principals: Lindesmith, Lisa C., Donaldson, Eric F., Beltramello, Martina, Pintus, Stefania, Corti, Davide, Swanstrom, Jesica, Debbink, Kari, Jones, Taylor A., Lanzavecchia, Antonio, Baric, Ralph S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136251/
https://ncbi.nlm.nih.gov/pubmed/24872579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01192-14
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