Immunogenetic Mechanisms Driving Norovirus GII.4 Antigenic Variation

Noroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections. The major capsid protein of GII.4 strains is evolving rapidly, resulting in new epidemic strains with altered antigenic potentials. To test if antigenic drift may contribute...

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Main Authors: Lindesmith, Lisa C., Beltramello, Martina, Donaldson, Eric F., Corti, Davide, Swanstrom, Jesica, Debbink, Kari, Lanzavecchia, Antonio, Baric, Ralph S.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355092/
https://ncbi.nlm.nih.gov/pubmed/22615565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002705
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