A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component

The ESX-1 secreted virulence factor ESAT-6 is one of the major and most well-studied virulence factors of Mycobacterium tuberculosis, given that its inactivation severely attenuates virulent mycobacteria. In this work, we show that clinical isolates of M. tuberculosis produce and secrete larger amou...

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Autori principali: Solans, Luis, Aguiló, Nacho, Samper, Sofía, Pawlik, Alexandre, Frigui, Wafa, Martín, Carlos, Brosch, Roland, Gonzalo-Asensio, Jesús
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Molecular Genomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136221/
https://ncbi.nlm.nih.gov/pubmed/24891105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01824-14
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