Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator

The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successful infection. Using transcriptome sequencing, we f...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Abdallah, Abdallah M., Weerdenburg, Eveline M., Guan, Qingtian, Ummels, Roy, Borggreve, Stephanie, Adroub, Sabir A., Malas, Tareq B., Naeem, Raeece, Zhang, Huoming, Otto, Thomas D., Bitter, Wilbert, Pain, Arnab
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343904/
https://ncbi.nlm.nih.gov/pubmed/30673778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211003
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