Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations

Although Bacillus Calmette-Guérin (BCG) vaccines against tuberculosis have been available for more than 90 years, their effectiveness has been hindered by variable protective efficacy and a lack of lasting memory responses. One factor contributing to this variability may be the diversity of the BCG...

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Publicado no:Sci Rep
Main Authors: Abdallah, Abdallah M., Hill-Cawthorne, Grant A., Otto, Thomas D., Coll, Francesc, Guerra-Assunção, José Afonso, Gao, Ge, Naeem, Raeece, Ansari, Hifzur, Malas, Tareq B., Adroub, Sabir A., Verboom, Theo, Ummels, Roy, Zhang, Huoming, Panigrahi, Aswini Kumar, McNerney, Ruth, Brosch, Roland, Clark, Taane G., Behr, Marcel A., Bitter, Wilbert, Pain, Arnab
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614345/
https://ncbi.nlm.nih.gov/pubmed/26487098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15443
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