Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

Cholesterol-oximes TRO19622 and TRO40303 target outer mitochondrial membrane proteins and have beneficial effects in preclinical models of neurodegenerative diseases leading to their advancement to clinical trials. Dopaminergic neurons degenerate in Parkinson’s disease (PD) and are prone to oxidativ...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Richter, Franziska, Gao, Fuying, Medvedeva, Vera, Lee, Patrick, Bove, Nicholas, Fleming, Sheila M., Michaud, Magali, Lemesre, Vincent, Patassini, Stefano, De La Rosa, Krystal, Mulligan, Caitlin K., Sioshansi, Pedrom, Zhu, Chunni, Coppola, Giovanni, Bordet, Thierry, Pruss, Rebecca, Chesselet, Marie-Françoise
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135465/
https://ncbi.nlm.nih.gov/pubmed/24844147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.05.012
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars