Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

Cholesterol-oximes TRO19622 and TRO40303 target outer mitochondrial membrane proteins and have beneficial effects in preclinical models of neurodegenerative diseases leading to their advancement to clinical trials. Dopaminergic neurons degenerate in Parkinson’s disease (PD) and are prone to oxidativ...

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Détails bibliographiques
Auteurs principaux: Richter, Franziska, Gao, Fuying, Medvedeva, Vera, Lee, Patrick, Bove, Nicholas, Fleming, Sheila M., Michaud, Magali, Lemesre, Vincent, Patassini, Stefano, De La Rosa, Krystal, Mulligan, Caitlin K., Sioshansi, Pedrom, Zhu, Chunni, Coppola, Giovanni, Bordet, Thierry, Pruss, Rebecca, Chesselet, Marie-Françoise
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135465/
https://ncbi.nlm.nih.gov/pubmed/24844147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.05.012
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