Stochastic but highly coordinated protein unfolding and translocation by the CIpXP proteolytic machine

CIpXP and other AAA+ proteases recognize, mechanically unfold, and translocate target proteins into a chamber for proteolysis. It is not known if these remarkable molecular machines operate by a stochastic or sequential mechanism or how power strokes relate to the ATP-hydrolysis cycle. Single-molecu...

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Autores principales: Cordova, Juan Carlos, Olivares, Adrian O., Shin, Yongdae, Stinson, Benjamin M., Calmat, Stephane, Schmitz, Karl R., Aubin-Tam, Marie-Eve, Baker, Tania A., Lang, Matthew J., Sauer, Robert T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134808/
https://ncbi.nlm.nih.gov/pubmed/25083874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.043
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