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Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine
All cells employ ATP-powered proteases for protein-quality control and regulation. In the ClpXP protease, ClpX is a AAA+ machine that recognizes specific protein substrates, unfolds these molecules, and then translocates the denatured polypeptide through a central pore and into ClpP for degradation....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3108460/ https://ncbi.nlm.nih.gov/pubmed/21496645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.036 |
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