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Stochastic but highly coordinated protein unfolding and translocation by the CIpXP proteolytic machine
CIpXP and other AAA+ proteases recognize, mechanically unfold, and translocate target proteins into a chamber for proteolysis. It is not known if these remarkable molecular machines operate by a stochastic or sequential mechanism or how power strokes relate to the ATP-hydrolysis cycle. Single-molecu...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134808/ https://ncbi.nlm.nih.gov/pubmed/25083874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.043 |
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