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Dissection of axial-pore loop function during unfolding and translocation by a AAA+ proteolytic machine

In the axial channels of ClpX and related hexameric AAA+ protein-remodeling rings, the pore-1 loops are thought to play important roles in engaging, mechanically unfolding, and translocating protein substrates. How these loops perform these functions and whether they also prevent substrate dissociat...

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Библиографические подробности
Опубликовано в: :Cell Rep
Главные авторы: Iosefson, Ohad, Olivares, Adrian O., Baker, Tania A., Sauer, Robert T.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536184/
https://ncbi.nlm.nih.gov/pubmed/26235618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.007
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