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Mechanochemical basis of protein degradation by a double-ring AAA+ machine

Molecular machines containing double or single AAA+ rings power energy-dependent protein degradation and other critical cellular processes, including disaggregation and remodeling of macromolecular complexes. How the mechanical activities of double-ring and single-ring AAA+ enzymes differ is unknown...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Olivares, Adrian O., Nager, Andrew R., Iosefson, Ohad, Sauer, Robert T., Baker, Tania A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190165/
https://ncbi.nlm.nih.gov/pubmed/25195048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2885
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