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PrP(Sc)-specific antibodies do not induce prion disease or misfolding of PrP(C) in highly susceptible Tga20 mice

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders caused by misfolding of a cellular protein PrP(C) into an infectious conformation PrP(Sc). Previously our group demonstrated induction of PrP(Sc)-specific antibodies with a SN6b vaccine that targets regions of the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Määttänen, Pekka, Taschuk, Ryan, Ross, Li, Marciniuk, Kristen, Bertram, Lisa, Potter, Andrew, Cashman, Neil R, Napper, Scott
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134347/
https://ncbi.nlm.nih.gov/pubmed/24105298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.26639
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