Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes

Species, as well as individuals within species, have unique susceptibilities to prion infection that are likely based on sequence differences in cellular prion protein (PrP(C)). Species barriers to transmission also reflect PrP(C) sequence differences. Defining the structure-activity relationship of...

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Hlavní autoři: Madampage, Claudia Avis, Marciniuk, Kristen, Määttänen, Pekka, Cashman, Neil R, Potter, Andrew, Lee, Jeremy S, Napper, Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201620/
https://ncbi.nlm.nih.gov/pubmed/24401607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.27502
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