Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie

Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases affecting a wide range of mammalian species. They are caused by prions, a proteinaceous pathogen essentially composed of PrP(Sc), an abnormal isoform of the host encoded cellular prion protein PrPC. Constraine...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Sarradin, Pierre, Viglietta, Céline, Limouzin, Claude, Andréoletti, Olivier, Daniel-Carlier, Nathalie, Barc, Céline, Leroux-Coyau, Mathieu, Berthon, Patricia, Chapuis, Jérôme, Rossignol, Christelle, Gatti, Jean-Luc, Belghazi, Maya, Labas, Valérie, Vilotte, Jean-Luc, Béringue, Vincent, Lantier, Frédéric, Laude, Hubert, Houdebine, Louis-Marie
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527776/
https://ncbi.nlm.nih.gov/pubmed/26248157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005077
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