Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice

Mammalian prions are proteinaceous infectious agents composed of misfolded assemblies of the host-encoded, cellular prion protein (PrP). Physiologically, the N-terminal polybasic region of residues 23 to 31 of PrP has been shown to be involved in its endocytic trafficking and interactions with glyco...

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Vydáno v:J Virol
Hlavní autoři: Khalifé, Manal, Reine, Fabienne, Paquet-Fifield, Sophie, Castille, Johan, Herzog, Laetitia, Vilotte, Marthe, Moudjou, Mohammed, Moazami-Goudarzi, Katayoun, Makhzami, Samira, Passet, Bruno, Andréoletti, Olivier, Vilette, Didier, Laude, Hubert, Béringue, Vincent, Vilotte, Jean-Luc
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Prions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719590/
https://ncbi.nlm.nih.gov/pubmed/26608316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02805-15
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