Markedly Increased Susceptibility to Natural Sheep Scrapie of Transgenic Mice Expressing Ovine PrP

The susceptibility of sheep to scrapie is known to involve, as a major determinant, the nature of the prion protein (PrP) allele, with the VRQ allele conferring the highest susceptibility to the disease. Transgenic mice expressing in their brains three different ovine PrP(VRQ)-encoding transgenes un...

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Detalhes bibliográficos
Main Authors: Vilotte, Jean-Luc, Soulier, Solange, Essalmani, Rachid, Stinnakre, Marie-George, Vaiman, Daniel, Lepourry, Laurence, Da Silva, Jose Costa, Besnard, Nathalie, Dawson, Mike, Buschmann, Anne, Groschup, Martin, Petit, Stephanie, Madelaine, Marie-Francoise, Rakatobe, Sabine, Le Dur, Annick, Vilette, Didier, Laude, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114313/
https://ncbi.nlm.nih.gov/pubmed/11390599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.5977-5984.2001
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