Markedly Increased Susceptibility to Natural Sheep Scrapie of Transgenic Mice Expressing Ovine PrP

The susceptibility of sheep to scrapie is known to involve, as a major determinant, the nature of the prion protein (PrP) allele, with the VRQ allele conferring the highest susceptibility to the disease. Transgenic mice expressing in their brains three different ovine PrP(VRQ)-encoding transgenes un...

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Vydáno v:	J Virol
Hlavní autoři:	Vilotte, Jean-Luc, Soulier, Solange, Essalmani, Rachid, Stinnakre, Marie-George, Vaiman, Daniel, Lepourry, Laurence, Da Silva, Jose Costa, Besnard, Nathalie, Dawson, Mike, Buschmann, Anne, Groschup, Martin, Petit, Stephanie, Madelaine, Marie-Francoise, Rakatobe, Sabine, Le Dur, Annick, Vilette, Didier, Laude, Hubert
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Pathogenesis and Immunity
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114313/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390599/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.13.5977-5984.2001
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