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PrP(Sc)-specific antibodies do not induce prion disease or misfolding of PrP(C) in highly susceptible Tga20 mice

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders caused by misfolding of a cellular protein PrP(C) into an infectious conformation PrP(Sc). Previously our group demonstrated induction of PrP(Sc)-specific antibodies with a SN6b vaccine that targets regions of the...

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Bibliografiske detaljer
Main Authors: Määttänen, Pekka, Taschuk, Ryan, Ross, Li, Marciniuk, Kristen, Bertram, Lisa, Potter, Andrew, Cashman, Neil R, Napper, Scott
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134347/
https://ncbi.nlm.nih.gov/pubmed/24105298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.26639
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