Mechanosensitive release of ATP through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain

As ATP released from astrocytes can modulate many neural signaling systems, the triggers of and pathways for this ATP release are important. Here, the ability of mechanical strain to trigger ATP release through pannexin channels, and the effects of sustained strain on pannexin expression, were exami...

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Main Authors: Beckel, Jonathan M., Argall, Arthur J., Lim, Jason C., Xia, Jingsheng, Lu, Wennan, Coffey, Erin E., Macarak, Edward J., Shahidullah, Mohammed, Delamere, Nicholas A., Zode, Gulab S., Sheffield, Val C., Shestopalov, Valery I., Laties, Alan M., Mitchell, Claire H.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133947/
https://ncbi.nlm.nih.gov/pubmed/24839011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22695
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