Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye

PURPOSE. The cellular mechanisms linking elevated IOP with glaucomatous damage remain unresolved. Mechanical strains and short-term increases in IOP can trigger ATP release from retinal neurons and astrocytes, but the response to chronic IOP elevation is unknown. As excess extracellular ATP can incr...

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Dades bibliogràfiques
Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Lu, Wennan, Hu, HuiLing, Sévigny, Jean, Gabelt, B'Ann T., Kaufman, Paul L., Johnson, Elaine C., Morrison, John C., Zode, Gulab S., Sheffield, Val C., Zhang, Xiulan, Laties, Alan M., Mitchell, Claire H.
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2015
Matèries:
Glaucoma
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439132/
https://ncbi.nlm.nih.gov/pubmed/26024091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15891
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