Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma

PURPOSE. Mutations in the myocilin gene (MYOC) are the most common known genetic cause of primary open-angle glaucoma (POAG). The purpose of this study was to determine whether topical ocular sodium 4-phenylbutyrate (PBA) treatment rescues glaucoma phenotypes in a mouse model of myocilin-associated...

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Detalhes bibliográficos
Main Authors: Zode, Gulab S., Bugge, Kevin E., Mohan, Kabhilan, Grozdanic, Sinisa D., Peters, Joseph C., Koehn, Demelza R., Anderson, Michael G., Kardon, Randy H., Stone, Edwin M., Sheffield, Val C.
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339917/
https://ncbi.nlm.nih.gov/pubmed/22328638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8837
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