Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully understood. Here, we report the development of a transgenic mouse model of POAG caused by the Y437H MYOC mutation; the mice are r...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Zode, Gulab S., Kuehn, Markus H., Nishimura, Darryl Y., Searby, Charles C., Mohan, Kabhilan, Grozdanic, Sinisa D., Bugge, Kevin, Anderson, Michael G., Clark, Abbot F., Stone, Edwin M., Sheffield, Val C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163970/
https://ncbi.nlm.nih.gov/pubmed/21821918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58183
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller