Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully understood. Here, we report the development of a transgenic mouse model of POAG caused by the Y437H MYOC mutation; the mice are r...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Zode, Gulab S., Kuehn, Markus H., Nishimura, Darryl Y., Searby, Charles C., Mohan, Kabhilan, Grozdanic, Sinisa D., Bugge, Kevin, Anderson, Michael G., Clark, Abbot F., Stone, Edwin M., Sheffield, Val C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163970/
https://ncbi.nlm.nih.gov/pubmed/21821918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58183
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars