Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully understood. Here, we report the development of a transgenic mouse model of POAG caused by the Y437H MYOC mutation; the mice are r...

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Detalhes bibliográficos
Main Authors: Zode, Gulab S., Kuehn, Markus H., Nishimura, Darryl Y., Searby, Charles C., Mohan, Kabhilan, Grozdanic, Sinisa D., Bugge, Kevin, Anderson, Michael G., Clark, Abbot F., Stone, Edwin M., Sheffield, Val C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163970/
https://ncbi.nlm.nih.gov/pubmed/21821918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58183
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