Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin

Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in elevated IOP are the most common genetic causes of POAG. We have previously shown that mutant myocilin accumulates in the ER and induc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Kasetti, Ramesh B., Maddineni, Prabhavathi, Kiehlbauch, Charles, Patil, Shruti, Searby, Charles C., Levine, Beth, Sheffield, Val C., Zode, Gulab S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021112/
https://ncbi.nlm.nih.gov/pubmed/33539326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143359
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