Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X(7) receptors

Mechanical deformation produces complex effects on neuronal systems, some of which can lead to dysfunction and neuronal death. While astrocytes are known to respond to mechanical forces, it is not clear whether neurons can also respond directly. We examined mechanosensitive ATP release and the physi...

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Detalhes bibliográficos
Main Authors: Xia, Jingsheng, Lim, Jason C, Lu, Wennan, Beckel, Jonathan M, Macarak, Edward J, Laties, Alan M, Mitchell, Claire H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Neuroscience: Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424753/
https://ncbi.nlm.nih.gov/pubmed/22411013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.227983
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