Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X(7) receptors

Mechanical deformation produces complex effects on neuronal systems, some of which can lead to dysfunction and neuronal death. While astrocytes are known to respond to mechanical forces, it is not clear whether neurons can also respond directly. We examined mechanosensitive ATP release and the physi...

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Hlavní autoři: Xia, Jingsheng, Lim, Jason C, Lu, Wennan, Beckel, Jonathan M, Macarak, Edward J, Laties, Alan M, Mitchell, Claire H
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2012
Témata:
Neuroscience: Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424753/
https://ncbi.nlm.nih.gov/pubmed/22411013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.227983
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