The P2X7 receptor links mechanical strain to cytokine IL-6 upregulation and release in neurons and astrocytes

BACKGROUND: Mechanical strain in neural tissues can lead to the upregulation and release of multiple cytokines including IL-6. In the retina, the mechanosensitive release of ATP can autostimulate P2X7 receptors on both retinal ganglion cell neurons and optic nerve head astrocytes. Here we asked whet...

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Bibliographic Details
Published in:J Neurochem
Main Authors: Lu, Wennan, Albalawi, Farraj, Beckel, Jonathan M., Lim, Jason C., Laties, Alan M., Mitchell, Claire H.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408351/
https://ncbi.nlm.nih.gov/pubmed/28244110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13998
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