Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels

Cross-reactions between innate immunity, lysosomal function, and purinergic pathways may link signaling systems in cellular pathologies. We found activation of toll-like receptor 3 (TLR3) triggers lysosomal ATP release from both astrocytes and retinal pigmented epithelial (RPE) cells. ATP efflux was...

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Pubblicato in:Sci Rep
Autori principali: Beckel, Jonathan M., Gómez, Néstor Más, Lu, Wennan, Campagno, Keith E., Nabet, Bardia, Albalawi, Farraj, Lim, Jason C., Boesze-Battaglia, Kathleen, Mitchell, Claire H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893592/
https://ncbi.nlm.nih.gov/pubmed/29636491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23877-3
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