Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation

The transient receptor potential cation channel mucolipin 1 (TRPML1) channel is a conduit for lysosomal calcium efflux, and channel activity may be affected by lysosomal contents. The lysosomes of retinal pigmented epithelial (RPE) cells are particularly susceptible to build-up of lysosomal waste pr...

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Udgivet i:FASEB J
Main Authors: Gómez, Néstor Más, Lu, Wennan, Lim, Jason C., Kiselyov, Kirill, Campagno, Keith E., Grishchuk, Yulia, Slaugenhaupt, Susan A., Pfeffer, Bruce A., Fliesler, Steven J., Mitchell, Claire H.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888396/
https://ncbi.nlm.nih.gov/pubmed/29030399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700220RR
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