PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium

At the early stages of carcinogenesis, transformation occurs in single cells within tissues. In an epithelial monolayer, such mutated cells are recognized by their normal neighbors and are often apically extruded. The apical extrusion requires cytoskeletal reorganization and changes in cell shape, b...

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Bibliografske podrobnosti
Main Authors: Anton, Katarzyna A., Sinclair, John, Ohoka, Atsuko, Kajita, Mihoko, Ishikawa, Susumu, Benz, Peter M., Renne, Thomas, Balda, Maria, Jorgensen, Claus, Matter, Karl, Fujita, Yasuyuki
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Short Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132389/
https://ncbi.nlm.nih.gov/pubmed/24963131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.149674
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