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PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium
At the early stages of carcinogenesis, transformation occurs in single cells within tissues. In an epithelial monolayer, such mutated cells are recognized by their normal neighbors and are often apically extruded. The apical extrusion requires cytoskeletal reorganization and changes in cell shape, b...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132389/ https://ncbi.nlm.nih.gov/pubmed/24963131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.149674 |
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