PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium

At the early stages of carcinogenesis, transformation occurs in single cells within tissues. In an epithelial monolayer, such mutated cells are recognized by their normal neighbors and are often apically extruded. The apical extrusion requires cytoskeletal reorganization and changes in cell shape, b...

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Bibliografiske detaljer
Main Authors: Anton, Katarzyna A., Sinclair, John, Ohoka, Atsuko, Kajita, Mihoko, Ishikawa, Susumu, Benz, Peter M., Renne, Thomas, Balda, Maria, Jorgensen, Claus, Matter, Karl, Fujita, Yasuyuki
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2014
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132389/
https://ncbi.nlm.nih.gov/pubmed/24963131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.149674
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