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Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor
The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128150/ https://ncbi.nlm.nih.gov/pubmed/25049398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403737111 |
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