Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Carr, Simon M., Munro, Shonagh, Zalmas, Lykourgos-Panagiotis, Fedorov, Oleg, Johansson, Catrine, Krojer, Tobias, Sagum, Cari A., Bedford, Mark T., Oppermann, Udo, La Thangue, Nicholas B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128150/
https://ncbi.nlm.nih.gov/pubmed/25049398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403737111
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi